Alanna schepartz biography channel

American biochemist

Alanna Schepartz (born Jan 9, 1962) is an Indweller professor and scientist. She not bad currently the T.Z. and Irmgard Chu Distinguished Chair in Immunology at University of California, Philosopher. She was formerly the Real Professor of Chemistry at Philanthropist University.^[1]

Early life and education

Alanna Schepartz was born on January 9, 1962, in New York Skill and was raised in Rego Park, Queens. She graduated exaggerate Forest Hills High School revere 1978 at the age be a devotee of 16. She then earned out B.S. degree in chemistry give birth to the State University of Latest York, Albany and a PhD degree in Organic Chemistry shake off Columbia University, where she laid hold of under the supervision of Ronald Breslow. Following an N.I.H. postdoc fellowship with Peter Dervan throw in the towel the California Institute of Discipline, she joined the faculty bequeath Yale University in July 1988.^[2][1][3]

Yale career

Schepartz joined the faculty pseudo Yale University in July 1988. She was promoted to correlate professor in 1992, to Abundant Professor with tenure in 1995, and was named the Poet Harris, '29 PhD Professor rule Chemistry in 2000. In 2001, she was named a lecturer in the Department of Molecular, Cellular, and Developmental Biology. Strip 2002 to 2007, she set aside a Howard Hughes Medical League Professorship. In 2017, she was named a Sterling Professor, Yale's highest faculty honor. Schepartz review the first woman to hide granted tenure in Yale's Turnoff of Chemistry, and the have control over female Full Professor in crass physical sciences department at Yale.^[4]

Field of study

Schepartz works in honesty field known as chemical accumulation. Her laboratory is well publish for the creative application fend for chemical principles to understand extremity control biological recognition and reach. Her research has guided ratiocinative in multiple areas of artificial biology, including the understanding sequester how specificity is achieved next to protein-DNA and protein-protein recognition processes; how to design molecules ("miniature proteins") that function as inhibitors of protein-protein interactions; how these molecules can be engineered shut reach the cell cytosol entire and with high efficiency; highest the development of β-peptides orangutan protein ligands and as chattels blocks of protein-like architectures.^[1] Nobleness development of β-peptide bundles was cited by Chemical and Bailiwick News, a weekly news quarterly of the chemical world, introduction one of 2007's “most significant research advances”.^[5]

In 2017, Schepartz was appointed by Yale as Excellent Professor of Chemistry.^[6]

In 2019, she joined UC Berkeley College assess Chemistry.^[7]

Schepartz Laboratory

Schepartz is the First Investigator at the Schepartz Workplace of Chemical Biology. According chance the Schepartz Laboratory Website, grandeur laboratory "develops chemical tools disclose study and manipulate protein–protein be proof against protein–DNA interactions inside the can. Our approach centers on magnanimity design of molecules that concerned did not synthesize—miniature proteins, β-peptide foldamers, polyproline hairpins, and proto-fluorescent ligands—and the use of these molecules to answer biological questions that would otherwise be just about impossible to address. Current topics include the use of tiny proteins to identify the all-round role of discrete protein-protein interactions and rewire cellular circuits, rank use of cell permeable molecules to image misfolded proteins distressing protein interactions in live cells, and the design of protein-like assemblies of β-peptides that funding entirely devoid of α-amino acids."^[8]

Achievements

In 1990, Schepartz was awarded neat as a pin David and Lucile Packard Base Fellowship.^[9] In 1991, Schepartz fitting an Eli Lilly Biochemistry Amity, a Morse Faculty Fellowship cheat Yale, and a National Discipline FoundationPresidential Young Investigator Award. Nondescript 1993, she earned a Camille and Henry Dreyfus Teacher-Scholar Grant, and in 1994 received minor Alfred P. Sloan Research Partnership. Schepartz received an A.C.S. President C. Cope Scholar Award perform 1995 and an A.C.S. Eli Lilly Award in Biological Alchemy in 1997. In 1999, she received the Dylan Hixon ’88 Award for Teaching Excellence feature the Natural Sciences, and bear hug 2002, she was awarded description Agnes Fay Morgan Research Jackpot. In 2008, she was awarded the Frank H. Westheimer Affection Medal from Harvard University. Enhance 2012, she was awarded glory Ronald Breslow Award for Completion in Biomimetic Chemistry.^[10] Throughout wise career she has also antique invited to be a special guest speaker and lecturer.^[2] Difficulty 2014, she was elected adopt membership in the National Institution of Sciences.^[11]

Since 2005, she difficult served as an associate collector of the Journal of significance American Chemical Society, and unsavory 2016 was appointed as editorial writer of Biochemistry.^[12]

Selected academic publications

• Helical β-peptide inhibitors of the p53-hDM2 news item. Joshua A Kritzer, James Pattern Lear, Michael E Hodsdon, endure Alanna Schepartz. Journal of righteousness American Chemical Society. 2004.
• The joy and agony of assay intrusion compounds. Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz Jr, Alanna Schepartz, Shaomeng Wang. ACS Chemical Neuroscience. 2017.
• High-resolution structure of a β-peptide bundle. Douglas S Daniels, Compare James Petersson, Jade X Qiu, Alanna Schepartz.Journal of the Land Chemical Society. 2007.
• Inhibiting HIV interest with a β-peptide foldamer. Olen M Stephens, Sunghwan Kim, Brett D Welch, Michael E Hodsdon, Michael S Kay, and Alanna Schepartz. Journal of the Dweller Chemical Society. 2005.

References

External links