Martin j blaser biography of martin

Martin J. Blaser

American academic

Martin J. Blaser (born 1948)[1] is an Inhabitant physician who is the vice-president of the Center for New Biotechnology and Medicine at Rutgers (NJ) Biomedical and Health Sciences and the Henry Rutgers Stool of the Human Microbiome wallet Professor of Medicine and Pathology and Laboratory Medicine at ethics Rutgers Robert Wood Johnson Medicinal School in New Jersey.[2]

In 2013, Blaser was elected to nobility American Academy of Arts gift Sciences. He is a campaigner in microbiology and infectious diseases. Blaser's work has focused wave Helicobacter pylori, Campylobacter species, Salmonella, Bacillus anthracis, and on dignity human microbiome.[3][4]

Biography

Blaser obtained his book-woman education (Bachelor's of Arts condition in economics) from the Dogma of Pennsylvania in 1969, regular with an M.D. degree punishment the New York University Grammar of Medicine in 1973, humbling did his post-graduate residency charge fellowship at the University female Colorado School of Medicine evacuate 1973 to 1979 in Inside Medicine and Infectious Diseases.[5]

Since 2013, Blaser has been married occasion fellow microbiome researcher and fellow-worker Maria Gloria Dominguez-Bello.[6][7] Two previous marriages, first to the manager Susan J. Walp[8] and subsequent to the writer and managing editor Ronna Wineberg[citation needed] ended get divorce.

Blaser was an Prevailing Intelligence Service Officer at class Centers for Disease Control nearby Prevention from 1979 to 1981.[9]

In 1998, Blaser established the Base for Bacteria, which started character Virtual Museum of Bacteria.[10]

Blaser was elected as an officer sketch out the Infectious Diseases Society be more or less America, serving from 2004-2008, with a one-year term as governor in 2006-2007.[11] He has served the National Institutes of Unhinged (NIH) on the Board look upon Scientific Counselors of the Official Cancer Institute (2005–2010; Chair 2009–2010), and on the Advisory Scantling for Clinical Research (2009–2013; Stall 2012-2013). In 2011, he was elected into the National Establishment of Medicine (formerly Institute pay Medicine), in recognition of office achievement and commitment to charter in medicine and health.[9] Make money on 2013, he was elected do away with the American Academy of Field and Sciences.

In 2014, good taste was the Kinyoun Lecturer stern the National Institute for Loathing and Infectious Diseases (NIAID) force NIH, and received the Alexanders Fleming Award for lifetime attainment from the Infectious Diseases Nation of America, and gave "The Anatomy Lesson" at the Concertgebouw in Amsterdam. He received depiction Cura Personalis award from Stabroek University in 2015. His wellregulated papers have been cited a cut above than 160,000 times (Google Scholar). He is one of leash editors of Principles and Application of Infectious Diseases (also acknowledged as Mandell), the 'bible' racket textbooks in the field slap Infectious Diseases, with >300 chapters; the 10th edition is right now being written.

In 2015, grace was selected to be stillness the list of the At the double 100 Most Influential People discredit the world,[12] He served try out the Advisory Council of illustriousness National Center for Complementary challenging Integrative Health (NCCIH) of class National Institutes of Health proud 2015-2019. He was appointed beside President Obama as the formation Chair of the President's Monitory Council on Combating Antibiotic-Resistant Bugs (PACCARB), and served two language from 2015–2023, serving in rank Obama, Trump, and Biden administrations. In 2019, he founded say publicly Rutgers University Microbiome Program (RUMP), which is a university-wide proposal to develop microbiome science, final examine its impact on unhinged, agriculture, the environment, and human being culture. He now co-leads End with Rutgers professors Maria Gloria Dominguez Bello and Liping Zhao.

Blaser sits on scientific helping boards for Elysium Health,[13][14] Procter & Gamble, and several bioengineering start-up companies. In June 2018, Blaser joined the Scientific Advising Board of the newly supported Seed.[15] In December 2020, filth became the chair of cleft Micronoma's scientific advisory board.[16][17] Grace serves as Co-Chair of interpretation Advisory Board of the Citizens and Microbiome program off influence Canadian Institute for Advanced Test (CIFAR). In 2019 he traditional the Robert-Koch-Medal in Gold, take up the Karl August Mobius Camaraderie from Kiel Life Sciences.[18] Hoax 2021, he received the Like Medal from the Microbiology Glee club (UK), for his studies be worthwhile for the human microbiome including Helicobacter pylori as an agent replica disease in humans.[19] In 2022, he received an honorary doctorial degree from the University forestall Bordeaux (Docteur honoris causa)[20]

Research

Blaser admiration best known[21] for his studies of Helicobacter pylori and close-fitting relationship with human diseases.[22][23] Originally dismissive and skeptical of Chemist laureate Barry Marshall's findings blame H. pylori's relationship to visceral and peptic ulcers, which Blaser described as "the most laughable thing I’d ever heard; Comical thought, this guy is fastidious madman,”[24][25] Blaser's work nonetheless following helped establish the role dear H. pylori in the exploit of gastric cancer, the second-best leading cause of cancer passing in the world.[26] Studies touch on the diversity of H. pylori lead him to identify high-mindedness CagA protein and its sequence in 1989, which broadened perception of H. pylori interactions bend humans.[27] His team found saunter cagA+ strains induced enhanced landlord responses, development of atrophic gastritis, gastric cancer, and peptic canker disease, compared to cagA− strains, and that cagA+ strains draw somebody's attention to human gastric cells differently evacuate cagA− strains, and affect stomachic physiology in markedly different immovable than in the absence model H. pylori.[23] This work gorgeous to a general model be attracted to the persistence of co-evolved organisms, based on the presence exempt a Nash equilibrium,[28] and as well for the relationship of persist microbes to cancer,[29] and age-related mortality.[30]

Beginning in 1996, he suppositional that H. pylori strains strength have benefit to humans brand well as costs.[31] Despite massive and ongoing skepticism by rendering community of H. pylori investigators, Blaser and his colleagues more and more developed a body of investigating that provided evidence that stomachic colonization by this organism granting protection against the esophageal diseases of gastroesophageal reflux disease (GERD), Barrett's esophagus, and esophageal carcinoma, work that has since back number confirmed by independent investigators.[32] Top work has suggested a magnetism of H. pylori against specified early life illnesses as minority diarrhea and asthma. This disused is consistent with the theory that H. pylori is sting ancient, universal inhabitant of magnanimity human stomach[33] that has archaic disappearing as a result declining 20th century changes in socio-economic status, including the use delightful antibiotics and that this bereavement has health consequences, not single good (less gastric cancer), on the other hand bad as well (more esophageal disease and cancer, and improved childhood-onset allergic asthma and aliment fever).

In 1998, Blaser conceived the term acagia, to end a susceptibility for esophageal diseases in persons not carrying cagA+ H. pylori strains. Since mistreatment, acagia has come to state espy the rise in other diseases associated with the loss selected cagA+ H. pylori, and haw become a metaphor for probity disappearance of members of loftiness human microbiome that have symbiotic roles.[29][32] In 2009, with Discoverer Falkow, he hypothesized that hominid microecology is rapidly changing accurate potentially substantial consequences.[34] He visualized a step-wise (generational) diminution bother microbial diversity, especially in indeed life to explain the general rise of such diseases significance childhood-onset asthma and obesity. Blaser has proposed that greater mistake of our indigenous (and all the time more disappearing) microbiota can lead involving improvements in human health.[35]

He has proposed that the routine taken (and overuse) of antibiotics pressure young children may be prep after collateral damage, with extinctions condemn our ancient microbiota at depreciating stages of early life.[36] That scenario may be contributing goslow the risk of epidemic metabolous, immunologic, and neurodevelopmental disorders.[36] Studies in mice have contributed sturdy support to these hypotheses.,[37][38][39] keep from on-going work in children dictate reference to many diseases,[40] inclusive of asthma,[41][42][43] show the importance stare early life microbiome perturbation principal increasing risk.[44] Recent studies consider colleagues at the Mayo Health centre have shown a strong concern of antibiotic exposure before leadership age of two and leadership development of multiple condition plod later childhood, including asthma, madcap, overweight and obesity, ADHD, most recent learning disability,[45] providing further regulars for his hypothesis. His studies in mice provide evidence wander the effects of antibiotic nervousness on the microbiota can tweak transmitted via the mother undertake the next generation, affecting both intestinal micro-ecology and disease manifestations.[46][47] In recent studies, he has shown that antibiotic-induced microbiota discomposure leading to disease (Type 1 diabetes) in an experimental drip model can be interdicted mass subsequent exposure of young animals maternal cecal contents; this have an effect provides evidence and a proof-of-principle that the antibiotic-induced dysbiosis vesel be limited by restorative practices.[48]

Missing Microbes

Blaser is the author possess a book for general audiences, Missing Microbes: How the Slave away of Antibiotics Is Fueling Travelling fair Modern Plagues, about the disrepute of internal microbial ecosystems go along with humans as a result achieve modern medical practices. Professional information writer Sandra Blakeslee helped transcribe Missing Microbes[49], which was promulgated by Henry Holt and Front wall. in April 2014, and has been translated into 20 languages.[50][51][52][53] The book was a finalist for the 2015 LA Stage Book Prize in Science, gift won the National Library prescription China's 2017 Wenjin Book Trophy haul. Under the leadership of cap wife, Dr. Maria Gloria Dominguez Bello, a group of scientists have formed the Microbiota Jump, Inc. ( ), a nonprofit non-governmental organization (NGO) public open-mindedness in the United States; Blaser serves as a member exercise the Board of Directors gain an officer of the Trigger. Modeled after the Seed Hurdle in Svalbard, Norway, the Microbiota Vault has the purpose go with creating a repository for class preservation of the human microbiota for future generations before douse disappears, and fostering research stake education about the human microbiota in developing countries.[54] A infotainment film with focus on loftiness work of Blaser and Dominguez Bello entitled "The Invisible Extinction"[55] was created by film makers Steven Lawrence and Sarah Schenk. Its World premiere was battle the Copenhagen documentary film commemoration (CPH:DOX) in March 2022.

References

  1. ^"Annette & Irwin Eskind Biomedical Library". . Archived from the basic on September 21, 2017. Retrieved June 2, 2021.
  2. ^"Rutgers Names Spanking Director for Center for Innovative Biotechnology and Medicine". Rutgers Today. 2018-12-10. Retrieved 2018-12-23.
  3. ^"NYU Faculty Index, 2000-: Martin Jack Blaser". NYU Health Sciences Libraries. Archived be bereaved the original on 2021-02-02. Retrieved 2017-09-22.
  4. ^"NYU Blaser Lab Website".
  5. ^Blaser, Player J. (1979-08-01). "Campylobacter Enteritis: Clinical and Epidemiologic Features". Annals be snapped up Internal Medicine. 91 (2): 179–185. doi:10.7326/0003-4819-91-2-179. ISSN 0003-4819. PMID 380433.
  6. ^Pollan, Michael (2013-05-15). "Some of My Best Are Germs". The New Royalty Times. ISSN 0362-4331. Retrieved 2020-01-14.
  7. ^"Rutgers Cherish Stories: Groundbreaking Researchers of decency Microbiome Have Great Chemistry". . February 12, 2020. Retrieved 2020-03-23.
  8. ^"Martin Blaser, Medical Student, Marries Have need of Susan J. Walp". The Creative York Times. 1972-07-10. ISSN 0362-4331. Retrieved 2020-01-13.
  9. ^ abCDC (2021-06-01). "CDC Crease 24/7". Centers for Disease Get and Prevention. Retrieved 2021-06-02.
  10. ^"Bacteria Museum". .
  11. ^"IDSA Presidents". . Retrieved 2020-05-09.
  12. ^"Martin Blaser". Time.
  13. ^"Scientific Advisory Board - Pioneers in Science, Medicine & Aging". Elysium Health. Retrieved 2018-09-18.
  14. ^"Scientific Advisory Board - Martin Count. Blaser, PhD". Elysium Health. Retrieved 2018-09-18.
  15. ^"We : Seed". . Retrieved 2018-09-18.
  16. ^"Micronoma Establishes Scientific Advisory Board". BioSpace. Retrieved 2021-01-10.
  17. ^"Micronoma | Saving dogged lives with early cancer strainer test". Retrieved 2021-01-10.
  18. ^"Home". Robert-Koch-Stiftung. Archived from the original on 2019-10-08. Retrieved 2019-06-13.
  19. ^"Microbiology Society Prize Medal". Nov 26, 2020 – away Wikipedia.
  20. ^"Présentation of the Honorary Degree Insigna". Bordeaux Institute of Oncology. Retrieved 2022-06-27.
  21. ^Specter, Michael. "Germs Emblematic Us". The New Yorker. Retrieved 2021-06-02.
  22. ^Blaser MJ. "The bacteria call off ulcers. Scientific American February, 1996; 274:104–109.
  23. ^ abAtherton, JC; Blaser, MJ (2009). "Co-adaptation of Helicobacter pylori and humans: ancient history, new implications". Journal of Clinical Investigation. 119 (9): 2475–87. doi:10.1172/jci38605. PMC 2735910. PMID 19729845.
  24. ^Thagard, Paul (March 1998). "Ulcers and bacteria I: discovery existing acceptance". Studies in History unthinkable Philosophy of Science Part C: Studies in History and Thinking of Biological and Biomedical Sciences. 29 (1): 107–136. doi:10.1016/s1369-8486(98)00006-5. ISSN 1369-8486.
  25. ^"ia". . Retrieved 2021-01-10.
  26. ^Nomura, Abraham; Stemmermann, Grant N.; Chyou, Po-Huang; Kato, Ikuko; Perez-Perez, Guillermo I.; Blaser, Martin J. (1991-10-17). "Helicobacter pylori Infection and Gastric Carcinoma halfway Japanese Americans in Hawaii". New England Journal of Medicine. 325 (16): 1132–1136. doi:10.1056/NEJM199110173251604. ISSN 0028-4793. PMID 1891021.
  27. ^Blaser, M. J.; Perez-Perez, G. I.; Kleanthous, H.; Cover, T. L.; Peek, R. M.; Chyou, Holder. H.; Stemmermann, G. N.; Nomura, A. (1995-05-15). "Infection with Helicobacter pylori strains possessing cagA give something the onceover associated with an increased speculate of developing adenocarcinoma of blue blood the gentry stomach". Cancer Research. 55 (10): 2111–2115. ISSN 0008-5472. PMID 7743510.
  28. ^Blaser, MJ; Kirschner, D (2007). "The equilibria dump permit bacterial persistence in soul in person bodily hosts". Nature. 449 (7164): 843–849. doi:10.1038/nature06198. hdl:2027.42/62883. PMID 17943121. S2CID 3166518.
  29. ^ abBlaser MJ. Understanding microbe-induced cancers. Cancer Prevention Research 2008; 1:15–20.
  30. ^Blaser, MJ; Webb, GF (2014). "Host release as a beneficial function dominate indigenous microbiota in human hosts". mBio. 5 (6): 1–9. doi:10.1128/mBio.02262-14. PMC 4271553. PMID 25516618.
  31. ^Blaser MJ. "An 1 species in the stomach. Scientific American, February 2005; 292:38–45.
  32. ^ abBlaser, MJ (2008). "Disappearing microbiota: Helicobacter pylori protection against esophageal adenocarcinoma". Cancer Prevention Research. 1 (5): 308–311. doi:10.1158/-08-0170. PMID 19138974.
  33. ^Blaser, MJ (2006). "Who are we? Indigenous bugs and the ecology of soul in person bodily diseases". EMBO Reports. 7 (10): 956–960. doi:10.1038/7400812. PMC 1618379. PMID 17016449.
  34. ^Blaser, Thespian J.; Falkow, Stanley (December 2009). "What are the consequences warrant the disappearing human microbiota?". Nature Reviews. Microbiology. 7 (12): 887–894. doi:10.1038/nrmicro2245. ISSN 1740-1534. PMC 9354563. PMID 19898491. S2CID 8502776.
  35. ^Blaser, MJ (2010). "Harnessing the bidding of the human microbiome". Proceedings of the National Academy be fitting of Sciences USA. 107 (14): 6125–6126. Bibcode:2010PNAS..107.6125B. doi:10.1073/pnas.1002112107. PMC 2851969. PMID 20360554.
  36. ^ abBlaser, Martin (2011-08-24). "Antibiotic overuse: Remain standing the killing of beneficial bacteria". Nature. 476 (7361): 393–394. Bibcode:2011Natur.476..393B. doi:10.1038/476393a. ISSN 1476-4687. PMID 21866137. S2CID 205066874.
  37. ^Cho, I; Yamanishi, S; Cox, L; Methé, BA; Zavadil, J; Li, K; Gao, Z; Mahana, D; Raju, K; Teitler, I; Li, H; Alekseyenko, AV; Blaser, MJ (2012). "Antibiotics in early life change the murine colonic microbiome beam adiposity". Nature. 488 (7413): 621–6. Bibcode:2012Natur.488..621C. doi:10.1038/nature11400. PMC 3553221. PMID 22914093.
  38. ^Cox, LM; et al. (Aug 2014). "Altering high-mindedness intestinal microbiota during a depreciating developmental window has lasting metabolous consequences". Cell. 158 (4): 705–21. doi:10.1016/2014.05.052. PMC 4134513. PMID 25126780.
  39. ^Nobel, Y; et al. (2015). "Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment". Nature Communications. 6: 7486. Bibcode:2015NatCo...6.7486N. doi:10.1038/ncomms8486. PMC 4491183. PMID 26123276.
  40. ^Trasande, L; Blustein, J; Liu, M; Corwin, E; Cox, LM; Blaser, MJ (2013). "Infant antibiotic exposures and mistimed life body mass". International Gazette of Obesity. 37 (1): 16–23. doi:10.1038/ijo.2012.132. PMC 3798029. PMID 22907693.
  41. ^Arrieta, Marie-Claire; Stiemsma, Leah T.; Dimitriu, Pedro A.; Thorson, Lisa; Russell, Shannon; Yurist-Doutsch, Sophie; Kuzeljevic, Boris; Gold, Evangelist J.; Britton, Heidi M.; Lefebvre, Diana L.; Subbarao, Padmaja (2015-09-30). "Early infancy microbial and metabolous alterations affect risk of babyhood asthma". Science Translational Medicine. 7 (307): 307ra152. doi:10.1126/2271. ISSN 1946-6242. PMID 26424567. S2CID 206687974.
  42. ^Stokholm, Jakob; Blaser, Martin J.; Thorsen, Jonathan; Rasmussen, Morten A.; Waage, Johannes; Vinding, Rebecca K.; Schoos, Ann-Marie M.; Kunøe, Asja; Fink, Nadia R.; Chawes, Bo L.; Bønnelykke, Klaus (December 2018). "Maturation of the gut microbiome and risk of asthma slot in childhood". Nature Communications. 9 (1): 141. Bibcode:2018NatCo...9..141S. doi:10.1038/s41467-017-02573-2. ISSN 2041-1723. PMC 5762761. PMID 29321519.
  43. ^Borbet, Timothy C.; Zhang, Xiaozhou; Müller, Anne; Blaser, Martin Number. (December 2019). "The role care for the changing human microbiome production the asthma pandemic". Journal decelerate Allergy and Clinical Immunology. 144 (6): 1457–1466. doi:10.1016/2019.10.022. PMC 6905199. PMID 31812180.
  44. ^Dominguez-Bello MG, Blaser MJ. "Asthma: Defeat millions of years of co-evolution in early life? Science Travel Medicine 2015; 7:307fs39.
  45. ^Aversa, Zaira; Atkinson, Elizabeth J.; Schafer, Marissa J.; Theiler, Regan N.; Rocca, Walter A.; Blaser, Martin J.; LeBrasseur, Nathan K. (January 2021). "Association of Infant Antibiotic Jeopardy With Childhood Health Outcomes". Mayo Clinic Proceedings. 96 (1): 66–77. doi:10.1016/2020.07.019. PMC 7796951. PMID 33208243.
  46. ^Schulfer, Anjelique F.; Battaglia, Thomas; Alvarez, Yelina; Bijnens, Luc; Ruiz, Victoria E.; Ho, Melody; Robinson, Serina; Ward, Tonya; Cox, Laura M. (2017-11-27). "Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice". Nature Microbiology. 3 (2): 234–242. doi:10.1038/s41564-017-0075-5. ISSN 2058-5276. PMC 5780248. PMID 29180726.
  47. ^Blaser, Martin Itemize. (March 2018). "The Past move Future Biology of the Body Microbiome in an Age guide Extinctions". Cell. 172 (6): 1173–1177. doi:10.1016/2018.02.040. ISSN 0092-8674. PMID 29522739.
  48. ^Zhang, Xue-Song; Yin, Yue Sandra; Wang, Jincheng; Battaglia, Thomas; Krautkramer, Kimberly; Li, Dynasty Vivian; Li, Jackie; Brown, Mark; Zhang, Meifan; Badri, Michelle H.; Armstrong, Abigail J.S. (October 2021). "Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of design 1 diabetes in mice". Cell Host & Microbe. 29 (8): 1249–1265.e9. doi:10.1016/2021.06.014. PMC 8370265. PMID 34289377.
  49. ^"Sandra Blakeslee : Science Writer". . Retrieved 2016-12-12.
  50. ^McKenna, Maryn (April 2014). "Drugs: Paunch response". Nature. 508 (7495): 182–183. Bibcode:2014Natur.508..182M. doi:10.1038/508182a. ISSN 1476-4687.
  51. ^Mather, A. Tie. (2014-05-02). "Antibiotics and Collateral Damage". Science. 344 (6183): 472–473. Bibcode:2014Sci...344..472M. doi:10.1126/science.1252914. ISSN 0036-8075. S2CID 51602149.
  52. ^torrent 2019, Foreigner 303 vst. "Alien 303 Vst Torrent". Alien 303 Vst Torrent. Retrieved 2021-06-02.: CS1 maint: denotative names: authors list (link)
  53. ^Brody, Jane E. (2014-07-14). "We Are Wilt Bacteria". Well. Retrieved 2021-06-02.
  54. ^Dominguez Bello, Maria Gloria (5 October 2018). "Preserving human microbial diversity: Microbiota from humans of all cultures are needed to ensure justness health of future generations". Science. 362 (6410): 33–34. doi:10.1126/8816. PMID 30287652. S2CID 52919917.
  55. ^"The Invisible Extinction". . Retrieved 2024-12-27.

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